Cargando…

Targeting Mitochondrial Oncometabolites: A New Approach to Overcome Drug Resistance in Cancer

Drug resistance is the main obstacle for a successful cancer therapy. There are many mechanisms by which cancers avoid drug-mediated death, including alterations in cellular metabolism and apoptotic programs. Mitochondria represent the cell’s powerhouse and the connection between carbohydrate, lipid...

Descripción completa

Detalles Bibliográficos
Autores principales:	Godel, Martina, Ortone, Giacomo, Anobile, Dario Pasquale, Pasino, Martina, Randazzo, Giulio, Riganti, Chiara, Kopecka, Joanna
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8161136/ https://www.ncbi.nlm.nih.gov/pubmed/34065551 http://dx.doi.org/10.3390/pharmaceutics13050762

Ejemplares similares

Mitochondrial ROS drive resistance to chemotherapy and immune-killing in hypoxic non-small cell lung cancer
por: Salaroglio, Iris C., et al.
Publicado: (2022)

Overcoming drug resistance in glioblastoma: new options in sight?
por: Kopecka, Joanna, et al.
Publicado: (2021)

Strategies to Overcome Resistance to Immune-Based Therapies in Osteosarcoma
por: Hattinger, Claudia Maria, et al.
Publicado: (2023)

Hypoxia Dictates Metabolic Rewiring of Tumors: Implications for Chemoresistance
por: Belisario, Dimas Carolina, et al.
Publicado: (2020)

Editorial: Novel therapeutic approaches to target drug resistant tumors
por: Riganti, Chiara, et al.
Publicado: (2023)

Zoledronic acid overcomes chemoresistance and immunosuppression of malignant mesothelioma
por: Salaroglio, Iris Chiara, et al.
Publicado: (2014)

Long-Chain Acyl Coenzyme A Dehydrogenase, a Key Player in Metabolic Rewiring/Invasiveness in Experimental Tumors and Human Mesothelioma Cell Lines
por: Pouliquen, Daniel L., et al.
Publicado: (2023)

Carbonic anhydrase XII is a new therapeutic target to overcome chemoresistance in cancer cells
por: Kopecka, Joanna, et al.
Publicado: (2015)

Small Nucleolar RNAs Determine Resistance to Doxorubicin in Human Osteosarcoma
por: Godel, Martina, et al.
Publicado: (2020)

Insights into P-Glycoprotein Inhibitors: New Inducers of Immunogenic Cell Death
por: Kopecka, Joanna, et al.
Publicado: (2020)

New Tetrahydroisoquinoline Derivatives Overcome Pgp Activity in Brain-Blood Barrier and Glioblastoma Multiforme in Vitro
por: Salaroglio, Iris Chiara, et al.
Publicado: (2018)

Oncometabolites and the response to radiotherapy
por: Xiang, Kexu, et al.
Publicado: (2020)

Zoledronic acid-encapsulating self-assembling nanoparticles and doxorubicin: a combinatorial approach to overcome simultaneously chemoresistance and immunoresistance in breast tumors
por: Kopecka, Joanna, et al.
Publicado: (2016)

Electronic Coupling in 1,2,3-Triazole Bridged Ferrocenes and Its Impact on Reactive Oxygen Species Generation and Deleterious Activity in Cancer Cells
por: Biegański, Przemysław, et al.
Publicado: (2022)

Mitochondrial Delivery of Phenol Substructure Triggers Mitochondrial Depolarization and Apoptosis of Cancer Cells
por: Gazzano, Elena, et al.
Publicado: (2018)

The emerging role of fumarate as an oncometabolite
por: Yang, Ming, et al.
Publicado: (2012)

Oncometabolites: tailoring our genes
por: Nowicki, Stefan, et al.
Publicado: (2015)

Kynurenine: an oncometabolite in colon cancer
por: Venkateswaran, Niranjan, et al.
Publicado: (2020)

Metabolic Rewiring and the Characterization of Oncometabolites
por: Beyoğlu, Diren, et al.
Publicado: (2021)

Targeted Self-Emulsifying Drug Delivery Systems to Restore Docetaxel Sensitivity in Resistant Tumors
por: Campani, Virginia, et al.
Publicado: (2022)

ABCA1/ABCB1 Ratio Determines Chemo- and Immune-Sensitivity in Human Osteosarcoma
por: Belisario, Dimas Carolina, et al.
Publicado: (2020)

MRP1-Collateral Sensitizers as a Novel Therapeutic Approach in Resistant Cancer Therapy: An In Vitro and In Vivo Study in Lung Resistant Tumor
por: Riganti, Chiara, et al.
Publicado: (2020)

A chemoproteomic portrait of the oncometabolite fumarate
por: Kulkarni, Rhushikesh A., et al.
Publicado: (2019)

Oncometabolites: A new insight for oncology
por: Khatami, Fatemeh, et al.
Publicado: (2019)

ERK is a Pivotal Player of Chemo-Immune-Resistance in Cancer
por: Salaroglio, Iris C., et al.
Publicado: (2019)

New Strategies to Overcome Resistance to Chemotherapy and Immune System in Cancer
por: Riganti, Chiara, et al.
Publicado: (2019)

An Autocrine Cytokine/JAK/STAT-Signaling Induces Kynurenine Synthesis in Multidrug Resistant Human Cancer Cells
por: Campia, Ivana, et al.
Publicado: (2015)

SLC14A1 prevents oncometabolite accumulation and recruits HDAC1 to transrepress oncometabolite genes in urothelial carcinoma
por: Chan, Ti-Chun, et al.
Publicado: (2020)

Oncometabolites: Unconventional triggers of oncogenic signalling cascades
por: Sciacovelli, Marco, et al.
Publicado: (2016)

Oncometabolite induced primary cilia loss in pheochromocytoma
por: O’Toole, Samuel M, et al.
Publicado: (2018)

Increasing intratumor C/EBP-β LIP and nitric oxide levels overcome resistance to doxorubicin in triple negative breast cancer
por: Salaroglio, Iris C., et al.
Publicado: (2018)

ω-3 Long Chain Polyunsaturated Fatty Acids as Sensitizing Agents and Multidrug Resistance Revertants in Cancer Therapy
por: Corsetto, Paola Antonia, et al.
Publicado: (2017)

Zoledronic Acid Restores Doxorubicin Chemosensitivity and Immunogenic Cell Death in Multidrug-Resistant Human Cancer Cells
por: Riganti, Chiara, et al.
Publicado: (2013)

Oncometabolites as biomarkers in thyroid cancer: a systematic review
por: Khatami, Fatemeh, et al.
Publicado: (2019)

Clinical implications of the oncometabolite succinate in SDHx‐mutation carriers
por: Eijkelenkamp, Karin, et al.
Publicado: (2019)

Nitric oxide and P-glycoprotein modulate the phagocytosis of colon cancer cells
por: Kopecka, Joanna, et al.
Publicado: (2011)

iNOS activity is necessary for the cytotoxic and immunogenic effects of doxorubicin in human colon cancer cells
por: De Boo, Sara, et al.
Publicado: (2009)

IL17A Depletion Affects the Metabolism of Macrophages Treated with Gemcitabine
por: Roux, Cecilia, et al.
Publicado: (2021)

Human Phosphoglycerate Dehydrogenase Produces the Oncometabolite d-2-Hydroxyglutarate
por: Fan, Jing, et al.
Publicado: (2014)

The oncometabolite 2-hydroxyglutarate activates the mTOR signalling pathway
por: Carbonneau, Mélissa, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_mcgt67g0anusvvnhuh9ih2fgme