KEAP1 Cancer Mutants: A Large-Scale Molecular Dynamics Study of Protein Stability

We have performed 280 [Formula: see text] s of unbiased molecular dynamics (MD) simulations to investigate the effects of 12 different cancer mutations on Kelch-like ECH-associated protein 1 (KEAP1) (G333C, G350S, G364C, G379D, R413L, R415G, A427V, G430C, R470C, R470H, R470S and G476R), one of the f...

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Detalles Bibliográficos
Autores principales: Wilson, Carter J., Chang, Megan, Karttunen, Mikko, Choy, Wing-Yiu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8161161/
https://www.ncbi.nlm.nih.gov/pubmed/34065616
http://dx.doi.org/10.3390/ijms22105408

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8161161/
https://www.ncbi.nlm.nih.gov/pubmed/34065616
http://dx.doi.org/10.3390/ijms22105408

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