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A practical catalytic reductive amination of carboxylic acids
We report reductive alkylation reactions of amines using carboxylic acids as nominal electrophiles. The two-step reaction exploits the dual reactivity of phenylsilane and involves a silane-mediated amidation followed by a Zn(OAc)(2)-catalyzed amide reduction. The reaction is applicable to a wide ran...
Autores principales: | Stoll, Emma L., Tongue, Thomas, Andrews, Keith G., Valette, Damien, Hirst, David J., Denton, Ross M. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Royal Society of Chemistry
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8161228/ https://www.ncbi.nlm.nih.gov/pubmed/34123174 http://dx.doi.org/10.1039/d0sc02271c |
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