α-Synuclein A53T Binds to Transcriptional Adapter 2-Alpha and Blocks Histone H3 Acetylation

α-Synuclein (α-syn) is a hallmark amyloidogenic protein component of Lewy bodies in dopaminergic neurons affected by Parkinson’s disease (PD). Despite the multi-faceted gene regulation of α-syn in the nucleus, the mechanism underlying α-syn crosstalk in chromatin remodeling in PD pathogenesis remain...

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Detalles Bibliográficos
Autores principales: Lee, Ji-Yeong, Kim, Hanna, Jo, Areum, Khang, Rin, Park, Chi-Hu, Park, Soo-Jeong, Kwag, Eunsang, Shin, Joo-Ho
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8161267/
https://www.ncbi.nlm.nih.gov/pubmed/34065515
http://dx.doi.org/10.3390/ijms22105392

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8161267/
https://www.ncbi.nlm.nih.gov/pubmed/34065515
http://dx.doi.org/10.3390/ijms22105392

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