Mechanisms of TP53 Pathway Inactivation in Embryonic and Somatic Cells—Relevance for Understanding (Germ Cell) Tumorigenesis

The P53 pathway is the most important cellular pathway to maintain genomic and cellular integrity, both in embryonic and non-embryonic cells. Stress signals induce its activation, initiating autophagy or cell cycle arrest to enable DNA repair. The persistence of these signals causes either senescenc...

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Detalles Bibliográficos
Autores principales: Timmerman, Dennis M., Remmers, Tessa L., Hillenius, Sanne, Looijenga, Leendert H. J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8161298/
https://www.ncbi.nlm.nih.gov/pubmed/34065345
http://dx.doi.org/10.3390/ijms22105377

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8161298/
https://www.ncbi.nlm.nih.gov/pubmed/34065345
http://dx.doi.org/10.3390/ijms22105377

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