Harnessing CD16-Mediated NK Cell Functions to Enhance Therapeutic Efficacy of Tumor-Targeting mAbs

SIMPLE SUMMARY: Natural Killer (NK) cells play a major role in cancer immunotherapy based on tumor-targeting mAbs. NK cell-mediated tumor cell killing and cytokine secretion are powerfully stimulated upon interaction with IgG-opsonized tumor cells, through the aggregation of FcγRIIIA/CD16 IgG recept...

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Detalles Bibliográficos
Autores principales: Capuano, Cristina, Pighi, Chiara, Battella, Simone, De Federicis, Davide, Galandrini, Ricciarda, Palmieri, Gabriella
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8161310/
https://www.ncbi.nlm.nih.gov/pubmed/34065399
http://dx.doi.org/10.3390/cancers13102500

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8161310/
https://www.ncbi.nlm.nih.gov/pubmed/34065399
http://dx.doi.org/10.3390/cancers13102500

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