A Phase Ib Clinical Trial of Metformin and Chloroquine in Patients with IDH1-Mutated Solid Tumors

SIMPLE SUMMARY: Mutations in the isocitrate dehydrogenase 1 (IDH1) gene occur in high-grade chondrosarcoma, high-grade glioma and intrahepatic cholangiocarcinoma. Due to the lack of effective treatment options, these aggressive types of cancer have a dismal outcome. The metabolism of IDH1-mutated ca...

Descripción completa

Detalles Bibliográficos
Autores principales: Khurshed, Mohammed, Molenaar, Remco J., van Linde, Myra E., Mathôt, Ron A., Struys, Eduard A., van Wezel, Tom, van Noorden, Cornelis J. F., Klümpen, Heinz-Josef, Bovée, Judith V. M. G., Wilmink, Johanna W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8161333/
https://www.ncbi.nlm.nih.gov/pubmed/34069550
http://dx.doi.org/10.3390/cancers13102474

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8161333/
https://www.ncbi.nlm.nih.gov/pubmed/34069550
http://dx.doi.org/10.3390/cancers13102474

Ejemplares similares