Sarcomere function activates a p53-dependent DNA damage response that promotes polyploidization and limits in vivo cell engraftment

Human cardiac regeneration is limited by low cardiomyocyte replicative rates and progressive polyploidization by unclear mechanisms. To study this process, we engineer a human cardiomyocyte model to track replication and polyploidization using fluorescently tagged cyclin B1 and cardiac troponin T. U...

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Detalles Bibliográficos
Autores principales: Pettinato, Anthony M., Yoo, Dasom, VanOudenhove, Jennifer, Chen, Yu-Sheng, Cohn, Rachel, Ladha, Feria A., Yang, Xiulan, Thakar, Ketan, Romano, Robert, Legere, Nicolas, Meredith, Emily, Robson, Paul, Regnier, Michael, Cotney, Justin L., Murry, Charles E., Hinson, J. Travis
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8161465/
https://www.ncbi.nlm.nih.gov/pubmed/33951429
http://dx.doi.org/10.1016/j.celrep.2021.109088

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8161465/
https://www.ncbi.nlm.nih.gov/pubmed/33951429
http://dx.doi.org/10.1016/j.celrep.2021.109088

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