Enhanced G1 arrest and apoptosis via MDM4/MDM2 double knockdown and MEK inhibition in wild-type TP53 colon and gastric cancer cells with aberrant KRAS signaling

Murine double minute homolog 2 (MDM2) is an oncoprotein that induces p53 degradation via ubiquitin-ligase activity. MDM4 cooperates with MDM2-mediated p53 degradation, directly inhibiting p53 transcription by binding to its transactivation domain. Our previous study reported that the simultaneous in...

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Detalles Bibliográficos
Autores principales: Wang, Xiaoxuan, Yamamoto, Yoshiyuki, Imanishi, Mamiko, Zhang, Xiaochen, Sato, Masashi, Sugaya, Akinori, Hirose, Mitsuaki, Endo, Shinji, Natori, Yukikazu, Moriwaki, Toshikazu, Yamato, Kenji, Hyodo, Ichinosuke
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2021
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8161467/
https://www.ncbi.nlm.nih.gov/pubmed/34084225
http://dx.doi.org/10.3892/ol.2021.12819

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8161467/
https://www.ncbi.nlm.nih.gov/pubmed/34084225
http://dx.doi.org/10.3892/ol.2021.12819

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