Inhibition of Maternal-to-Fetal Transfer of IgG Antibodies by FcRn Blockade in a Mouse Model of Arthrogryposis Multiplex Congenita

OBJECTIVE: To determine whether blocking the neonatal Fc receptor (FcRn) during gestation with an anti-FcRn monoclonal antibody (mAb) reduces transfer of pathogenic maternal antibodies in utero and decreases the likelihood of maternal antibody-mediated neonatal disease in the offspring. METHODS: Usi...

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Detalles Bibliográficos
Autores principales: Coutinho, Ester, Jacobson, Leslie, Shock, Anthony, Smith, Bryan, Vernon, Anthony, Vincent, Angela
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8161539/
https://www.ncbi.nlm.nih.gov/pubmed/34045306
http://dx.doi.org/10.1212/NXI.0000000000001011

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8161539/
https://www.ncbi.nlm.nih.gov/pubmed/34045306
http://dx.doi.org/10.1212/NXI.0000000000001011

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