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Inhibition of Maternal-to-Fetal Transfer of IgG Antibodies by FcRn Blockade in a Mouse Model of Arthrogryposis Multiplex Congenita

OBJECTIVE: To determine whether blocking the neonatal Fc receptor (FcRn) during gestation with an anti-FcRn monoclonal antibody (mAb) reduces transfer of pathogenic maternal antibodies in utero and decreases the likelihood of maternal antibody-mediated neonatal disease in the offspring. METHODS: Usi...

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Detalles Bibliográficos
Autores principales:	Coutinho, Ester, Jacobson, Leslie, Shock, Anthony, Smith, Bryan, Vernon, Anthony, Vincent, Angela
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Lippincott Williams & Wilkins 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8161539/ https://www.ncbi.nlm.nih.gov/pubmed/34045306 http://dx.doi.org/10.1212/NXI.0000000000001011

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