In Vitro and In Vivo Comparison of 3,2-HOPO Versus Deferoxamine-Based Chelation of Zirconium-89 to the Antimesothelin Antibody Anetumab

Introduction: [(227)Th]Th-3,2-HOPO-MSLN-mAb, a mesothelin (MSLN)-targeted thorium-227 therapeutic conjugate, is currently in phase I clinical trial; however, direct PET imaging using this conjugate is technically challenging. Thus, using the same MSLN antibody, we synthesized 3,2-HOPO and deferoxami...

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Detalles Bibliográficos
Autores principales: Roy, Jyoti, Jagoda, Elaine M., Basuli, Falguni, Vasalatiy, Olga, Phelps, Tim E., Wong, Karen, Ton, Anita T., Hagemann, Urs B., Cuthbertson, Alan S., Cole, Patricia E., Hassan, Raffit, Choyke, Peter L., Lin, Frank I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Mary Ann Liebert, Inc., publishers 2021
Materias:
Original Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8161658/
https://www.ncbi.nlm.nih.gov/pubmed/34014767
http://dx.doi.org/10.1089/cbr.2020.4492

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8161658/
https://www.ncbi.nlm.nih.gov/pubmed/34014767
http://dx.doi.org/10.1089/cbr.2020.4492

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