Multi-targeting of functional cysteines in multiple conserved SARS-CoV-2 domains by clinically safe Zn-ejectors

We present a near-term treatment strategy to tackle pandemic outbreaks of coronaviruses with no specific drugs/vaccines by combining evolutionary and physical principles to identify conserved viral domains containing druggable Zn-sites that can be targeted by clinically safe Zn-ejecting compounds. B...

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Detalles Bibliográficos
Autores principales: Sargsyan, Karen, Lin, Chien-Chu, Chen, Ting, Grauffel, Cédric, Chen, Yi-Ping, Yang, Wei-Zen, Yuan, Hanna S., Lim, Carmay
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2020
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8162115/
https://www.ncbi.nlm.nih.gov/pubmed/34094251
http://dx.doi.org/10.1039/d0sc02646h

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8162115/
https://www.ncbi.nlm.nih.gov/pubmed/34094251
http://dx.doi.org/10.1039/d0sc02646h

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