Demonstration of the utility of DOS-derived fragment libraries for rapid hit derivatisation in a multidirectional fashion

Organic synthesis underpins the evolution of weak fragment hits into potent lead compounds. Deficiencies within current screening collections often result in the requirement of significant synthetic investment to enable multidirectional fragment growth, limiting the efficiency of the hit evolution p...

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Detalles Bibliográficos
Autores principales: Kidd, Sarah L., Fowler, Elaine, Reinhardt, Till, Compton, Thomas, Mateu, Natalia, Newman, Hector, Bellini, Dom, Talon, Romain, McLoughlin, Joseph, Krojer, Tobias, Aimon, Anthony, Bradley, Anthony, Fairhead, Michael, Brear, Paul, Díaz-Sáez, Laura, McAuley, Katherine, Sore, Hannah F., Madin, Andrew, O'Donovan, Daniel H., Huber, Kilian V. M., Hyvönen, Marko, von Delft, Frank, Dowson, Christopher G., Spring, David R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2020
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8162264/
https://www.ncbi.nlm.nih.gov/pubmed/34094333
http://dx.doi.org/10.1039/d0sc01232g

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8162264/
https://www.ncbi.nlm.nih.gov/pubmed/34094333
http://dx.doi.org/10.1039/d0sc01232g

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