Catalysis by the JmjC histone demethylase KDM4A integrates substrate dynamics, correlated motions and molecular orbital control

The N(ε)-methyl lysine status of histones is important in the regulation of eukaryotic transcription. The Fe(ii) and 2-oxoglutarate (2OG) -dependent JmjC domain enzymes are the largest family of histone N(ε)-methyl lysine demethylases (KDMs). The human KDM4 subfamily of JmjC KDMs is linked with mult...

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Detalles Bibliográficos
Autores principales: Ramanan, Rajeev, Chaturvedi, Shobhit S., Lehnert, Nicolai, Schofield, Christopher J., Karabencheva-Christova, Tatyana G., Christov, Christo Z.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2020
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8162366/
https://www.ncbi.nlm.nih.gov/pubmed/34094257
http://dx.doi.org/10.1039/d0sc03713c

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8162366/
https://www.ncbi.nlm.nih.gov/pubmed/34094257
http://dx.doi.org/10.1039/d0sc03713c

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