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Base-catalyzed aryl halide isomerization enables the 4-selective substitution of 3-bromopyridines
The base-catalyzed isomerization of simple aryl halides is presented and utilized to achieve the 4-selective etherification, hydroxylation and amination of 3-bromopyridines. Mechanistic studies support isomerization of 3-bromopyridines to 4-bromopyridines proceeds via pyridyne intermediates and that...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
The Royal Society of Chemistry
2020
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8162412/ https://www.ncbi.nlm.nih.gov/pubmed/34094310 http://dx.doi.org/10.1039/d0sc02689a |