Glycoside hydrolase stabilization of transition state charge: new directions for inhibitor design

Carbasugars are structural mimics of naturally occurring carbohydrates that can interact with and inhibit enzymes involved in carbohydrate processing. In particular, carbasugars have attracted attention as inhibitors of glycoside hydrolases (GHs) and as therapeutic leads in several disease areas. Ho...

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Detalles Bibliográficos
Autores principales: Ren, Weiwu, Farren-Dai, Marco, Sannikova, Natalia, Świderek, Katarzyna, Wang, Yang, Akintola, Oluwafemi, Britton, Robert, Moliner, Vicent, Bennet, Andrew J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2020
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8162432/
https://www.ncbi.nlm.nih.gov/pubmed/34094307
http://dx.doi.org/10.1039/d0sc04401f

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8162432/
https://www.ncbi.nlm.nih.gov/pubmed/34094307
http://dx.doi.org/10.1039/d0sc04401f

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