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Copper-mediated peptide arylation selective for the N-terminus

Polypeptides present remarkable selectivity challenges for chemical methods. Amino groups are ubiquitous in polypeptide structure, yet few paradigms exist for reactivity and selectivity in arylation of amine groups. This communication describes the utilization of boronic acid reagents bearing certai...

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Detalles Bibliográficos
Autores principales: Miller, Mary K., Wang, Haopei, Hanaya, Kengo, Zhang, Olivia, Berlaga, Alex, Ball, Zachary T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8162437/
https://www.ncbi.nlm.nih.gov/pubmed/34094308
http://dx.doi.org/10.1039/d0sc02933e