Unveiling the molecular mechanism of SARS-CoV-2 main protease inhibition from 137 crystal structures using algebraic topology and deep learning

Currently, there is neither effective antiviral drugs nor vaccine for coronavirus disease 2019 (COVID-19) caused by acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Due to its high conservativeness and low similarity with human genes, SARS-CoV-2 main protease (M(pro)) is one of the most favora...

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Detalles Bibliográficos
Autores principales: Nguyen, Duc Duy, Gao, Kaifu, Chen, Jiahui, Wang, Rui, Wei, Guo-Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2020
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8162568/
https://www.ncbi.nlm.nih.gov/pubmed/34123218
http://dx.doi.org/10.1039/d0sc04641h

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8162568/
https://www.ncbi.nlm.nih.gov/pubmed/34123218
http://dx.doi.org/10.1039/d0sc04641h

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