One-pot thiol–amine bioconjugation to maleimides: simultaneous stabilisation and dual functionalisation

Maleimide chemistry is widely used in the site-selective modification of proteins. However, hydrolysis of the resultant thiosuccinimides is required to provide robust stability to the bioconjugates. Herein, we present an alternative approach that affords simultaneous stabilisation and dual functiona...

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Detalles Bibliográficos
Autores principales: Wall, Archie, Wills, Alfie G., Forte, Nafsika, Bahou, Calise, Bonin, Lisa, Nicholls, Karl, Ma, Michelle T., Chudasama, Vijay, Baker, James R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2020
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8162801/
https://www.ncbi.nlm.nih.gov/pubmed/34094388
http://dx.doi.org/10.1039/d0sc05128d

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8162801/
https://www.ncbi.nlm.nih.gov/pubmed/34094388
http://dx.doi.org/10.1039/d0sc05128d

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