Cargando…

Meeting key synthetic challenges in amanitin synthesis with a new cytotoxic analog: 5′-hydroxy-6′-deoxy-amanitin

Appreciating the need to access synthetic analogs of amanitin, here we report the synthesis of 5′-hydroxy-6′-deoxy-amanitin, a novel, rationally-designed bioactive analog and constitutional isomer of α-amanitin, that is anticipated to be used as a payload for antibody drug conjugates. In completing...

Descripción completa

Detalles Bibliográficos
Autores principales: Pryyma, Alla, Matinkhoo, Kaveh, Wong, Antonio A. W. L., Perrin, David M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8162882/
https://www.ncbi.nlm.nih.gov/pubmed/34094418
http://dx.doi.org/10.1039/d0sc04150e