Acute pharmacological degradation of Helios destabilizes regulatory T cells

The zinc finger transcription factor Helios is critical for maintaining the identity, anergic phenotype, and suppressive activity of regulatory T cells. While it is an attractive target to enhance the efficacy of currently approved immunotherapies, no existing approaches can directly modulate Helios...

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Detalles Bibliográficos
Autores principales: Wang, Eric S., Verano, Alyssa L., Nowak, Radosław P., Yuan, J. Christine, Donovan, Katherine A., Eleuteri, Nicholas A., Yue, Hong, Ngo, Kenneth H., Lizotte, Patrick H., Gokhale, Prafulla C., Gray, Nathanael S., Fischer, Eric S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8162940/
https://www.ncbi.nlm.nih.gov/pubmed/34035522
http://dx.doi.org/10.1038/s41589-021-00802-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8162940/
https://www.ncbi.nlm.nih.gov/pubmed/34035522
http://dx.doi.org/10.1038/s41589-021-00802-w

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