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Acute pharmacological degradation of Helios destabilizes regulatory T cells
The zinc finger transcription factor Helios is critical for maintaining the identity, anergic phenotype, and suppressive activity of regulatory T cells. While it is an attractive target to enhance the efficacy of currently approved immunotherapies, no existing approaches can directly modulate Helios...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8162940/ https://www.ncbi.nlm.nih.gov/pubmed/34035522 http://dx.doi.org/10.1038/s41589-021-00802-w |