Production of novel pladienolide analogues through native expression of a pathway-specific activator

Aberrant splicing of pre-mRNA is implicated in many human genetic disorders. Small molecules that target the spliceosome are important leads as therapeutics and research tools, and one compound of significant interest is the polyketide natural product pladienolide B. Here, we describe the reactivati...

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Detalles Bibliográficos
Autores principales: Booth, Thomas J., Kalaitzis, John A., Vuong, Daniel, Crombie, Andrew, Lacey, Ernest, Piggott, Andrew M., Wilkinson, Barrie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2020
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8163091/
https://www.ncbi.nlm.nih.gov/pubmed/34094178
http://dx.doi.org/10.1039/d0sc01928c

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8163091/
https://www.ncbi.nlm.nih.gov/pubmed/34094178
http://dx.doi.org/10.1039/d0sc01928c

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