Macrocycle synthesis strategy based on step-wise “adding and reacting” three components enables screening of large combinatorial libraries

Macrocycles provide an attractive modality for drug development, but generating ligands for new targets is hampered by the limited availability of large macrocycle libraries. We have established a solution-phase macrocycle synthesis strategy in which three building blocks are coupled sequentially in...

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Detalles Bibliográficos
Autores principales: Mothukuri, Ganesh K., Kale, Sangram S., Stenbratt, Carl L., Zorzi, Alessandro, Vesin, Jonathan, Bortoli Chapalay, Julien, Deyle, Kaycie, Turcatti, Gerardo, Cendron, Laura, Angelini, Alessandro, Heinis, Christian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2020
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8163216/
https://www.ncbi.nlm.nih.gov/pubmed/34094158
http://dx.doi.org/10.1039/d0sc01944e

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8163216/
https://www.ncbi.nlm.nih.gov/pubmed/34094158
http://dx.doi.org/10.1039/d0sc01944e

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