CRISPR/Cas9 uPAR Gene Knockout Results in Tumor Growth Inhibition, EGFR Downregulation and Induction of Stemness Markers in Melanoma and Colon Carcinoma Cell Lines

uPAR is a globular protein, tethered to the cell membrane by a GPI-anchor involved in several cancer-related properties and its overexpression commonly correlates with poor prognosis and metastasis. We investigated the consequences of uPAR irreversible loss in human melanoma and colon cancer cell li...

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Detalles Bibliográficos
Autores principales: Biagioni, Alessio, Chillà, Anastasia, Del Rosso, Mario, Fibbi, Gabriella, Scavone, Francesca, Andreucci, Elena, Peppicelli, Silvia, Bianchini, Francesca, Calorini, Lido, Li Santi, Anna, Ragno, Pia, Margheri, Francesca, Laurenzana, Anna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8163229/
https://www.ncbi.nlm.nih.gov/pubmed/34055629
http://dx.doi.org/10.3389/fonc.2021.663225

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8163229/
https://www.ncbi.nlm.nih.gov/pubmed/34055629
http://dx.doi.org/10.3389/fonc.2021.663225

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