Cargando…

CRISPR/Cas9 uPAR Gene Knockout Results in Tumor Growth Inhibition, EGFR Downregulation and Induction of Stemness Markers in Melanoma and Colon Carcinoma Cell Lines

uPAR is a globular protein, tethered to the cell membrane by a GPI-anchor involved in several cancer-related properties and its overexpression commonly correlates with poor prognosis and metastasis. We investigated the consequences of uPAR irreversible loss in human melanoma and colon cancer cell li...

Descripción completa

Detalles Bibliográficos
Autores principales:	Biagioni, Alessio, Chillà, Anastasia, Del Rosso, Mario, Fibbi, Gabriella, Scavone, Francesca, Andreucci, Elena, Peppicelli, Silvia, Bianchini, Francesca, Calorini, Lido, Li Santi, Anna, Ragno, Pia, Margheri, Francesca, Laurenzana, Anna
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2021
Materias:	Oncology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8163229/ https://www.ncbi.nlm.nih.gov/pubmed/34055629 http://dx.doi.org/10.3389/fonc.2021.663225

Ejemplares similares

EGFR/uPAR interaction as druggable target to overcome vemurafenib acquired resistance in melanoma cells
por: Laurenzana, Anna, et al.
Publicado: (2019)

uPAR-expressing melanoma exosomes promote angiogenesis by VE-Cadherin, EGFR and uPAR overexpression and rise of ERK1,2 signaling in endothelial cells
por: Biagioni, Alessio, et al.
Publicado: (2020)

uPAR Controls Vasculogenic Mimicry Ability Expressed by Drug-Resistant Melanoma Cells
por: Andreucci, Elena, et al.
Publicado: (2022)

uPAR Knockout Results in a Deep Glycolytic and OXPHOS Reprogramming in Melanoma and Colon Carcinoma Cell Lines
por: Biagioni, Alessio, et al.
Publicado: (2020)

Melanoma cell therapy: Endothelial progenitor cells as shuttle of the MMP12 uPAR-degrading enzyme
por: Laurenzana, Anna, et al.
Publicado: (2014)

Anoikis Resistance as a Further Trait of Acidic-Adapted Melanoma Cells
por: Peppicelli, Silvia, et al.
Publicado: (2019)

Differential uPAR recruitment in caveolar-lipid rafts by GM1 and GM3 gangliosides regulates endothelial progenitor cells angiogenesis
por: Margheri, Francesca, et al.
Publicado: (2015)

The receptor for urokinase-plasminogen activator (uPAR) controls plasticity of cancer cell movement in mesenchymal and amoeboid migration style
por: Margheri, Francesca, et al.
Publicado: (2014)

Type II CRISPR/Cas9 approach in the oncological therapy
por: Biagioni, A., et al.
Publicado: (2017)

Tumor-tropic endothelial colony forming cells (ECFCs) loaded with near-infrared sensitive Au nanoparticles: A “cellular stove” approach to the photoablation of melanoma
por: Margheri, Giancarlo, et al.
Publicado: (2016)

Mature and progenitor endothelial cells perform angiogenesis also under protease inhibition: the amoeboid angiogenesis
por: Chillà, Anastasia, et al.
Publicado: (2018)

Publisher Correction to: delivery systems of CRISPR/Cas9-based cancer gene therapy
por: Biagioni, Alessio, et al.
Publicado: (2019)

miR-214-Enriched Extracellular Vesicles Released by Acid-Adapted Melanoma Cells Promote Inflammatory Macrophage-Dependent Tumor Trans-Endothelial Migration
por: Andreucci, Elena, et al.
Publicado: (2022)

Cell-Mediated Release of Nanoparticles as a Preferential Option for Future Treatment of Melanoma
por: Chillà, Anastasia, et al.
Publicado: (2020)

The carbonic anhydrase IX inhibitor SLC-0111 sensitises cancer cells to conventional chemotherapy
por: Andreucci, Elena, et al.
Publicado: (2018)

Correction: Desmoglein-2-Integrin Beta-8 Interaction Regulates Actin Assembly in Endothelial Cells: Deregulation in Systemic Sclerosis
por: Giusti, Betti, et al.
Publicado: (2013)

GDF5 Regulates TGFß-Dependent Angiogenesis in Breast Carcinoma MCF-7 Cells: In Vitro and In Vivo Control by Anti-TGFß Peptides
por: Margheri, Francesca, et al.
Publicado: (2012)

Desmoglein-2-Integrin Beta-8 Interaction Regulates Actin Assembly in Endothelial Cells: Deregulation in Systemic Sclerosis
por: Giusti, Betti, et al.
Publicado: (2013)

Delivery systems of CRISPR/Cas9-based cancer gene therapy
por: Biagioni, Alessio, et al.
Publicado: (2018)

FDG uptake in cancer: a continuing debate
por: Peppicelli, Silvia, et al.
Publicado: (2020)

Physicochemical aspects of the tumour microenvironment as drivers of vasculogenic mimicry
por: Andreucci, Elena, et al.
Publicado: (2022)

SOX2 as a novel contributor of oxidative metabolism in melanoma cells
por: Andreucci, Elena, et al.
Publicado: (2018)

Inflammatory cytokines induce vascular endothelial growth factor-C expression in melanoma-associated macrophages and stimulate melanoma lymph node metastasis
por: PEPPICELLI, SILVIA, et al.
Publicado: (2014)

Dynamic scenario of metabolic pathway adaptation in tumors and therapeutic approach
por: Peppicelli, Silvia, et al.
Publicado: (2015)

A potentiated cooperation of carbonic anhydrase IX and histone deacetylase inhibitors against cancer
por: Ruzzolini, Jessica, et al.
Publicado: (2019)

Extracellular Acidosis Differentially Regulates Estrogen Receptor β-Dependent EMT Reprogramming in Female and Male Melanoma Cells
por: Peppicelli, Silvia, et al.
Publicado: (2022)

The Carbonic Anhydrase IX inhibitor SLC-0111 as emerging agent against the mesenchymal stem cell-derived pro-survival effects on melanoma cells
por: Peppicelli, Silvia, et al.
Publicado: (2020)

New Pieces in the Puzzle of uPAR Role in Cell Migration Mechanisms
por: Gorrasi, Anna, et al.
Publicado: (2020)

The acidic tumor microenvironment drives a stem-like phenotype in melanoma cells
por: Andreucci, Elena, et al.
Publicado: (2020)

Identification of uPAR Variants Acting as ceRNAs in Leukaemia Cells
por: Alfieri, Mariaevelina, et al.
Publicado: (2022)

Inhibition of MMPs supports amoeboid angiogenesis hampering VEGF-targeted therapies via MLC and ERK 1/2 signaling
por: Chillà, Anastasia, et al.
Publicado: (2023)

Potential Role of HLA Class I Antigens in the Glycolytic Metabolism and Motility of Melanoma Cells
por: Peppicelli, Silvia, et al.
Publicado: (2019)

Olive phenols preserve lamin B1 expression reducing cGAS/STING/NFκB‐mediated SASP in ionizing radiation‐induced senescence
por: Frediani, Elena, et al.
Publicado: (2022)

Enhanced Antitumoral Activity and Photoacoustic Imaging Properties of AuNP‐Enriched Endothelial Colony Forming Cells on Melanoma
por: Armanetti, Paolo, et al.
Publicado: (2020)

Triazole RGD antagonist reverts TGFβ1-induced endothelial-to-mesenchymal transition in endothelial precursor cells
por: Bianchini, Francesca, et al.
Publicado: (2016)

Oleuropein, the Main Polyphenol of Olea europaea Leaf Extract, Has an Anti-Cancer Effect on Human BRAF Melanoma Cells and Potentiates the Cytotoxicity of Current Chemotherapies
por: Ruzzolini, Jessica, et al.
Publicado: (2018)

An Oleocanthal-Enriched EVO Oil Extract Induces the ROS Production in Gastric Cancer Cells and Potentiates the Effect of Chemotherapy
por: Peri, Sara, et al.
Publicado: (2022)

Cancer Glycolytic Dependence as a New Target of Olive Leaf Extract
por: Ruzzolini, Jessica, et al.
Publicado: (2020)

Nintedanib-αVβ6 Integrin Ligand Conjugates Reduce TGFβ-Induced EMT in Human Non-Small Cell Lung Cancer
por: Andreucci, Elena, et al.
Publicado: (2023)

Urokinase type plasminogen activator receptor (uPAR) as a new therapeutic target in cancer
por: Montuori, Nunzia, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_i3a958hk6t5m2nb9lodbqhgjat