A click-flipped enzyme substrate boosts the performance of the diagnostic screening for Hunter syndrome

We report on the unexpected finding that click modification of iduronyl azides results in a conformational flip of the pyranose ring, which led to the development of a new strategy for the design of superior enzyme substrates for the diagnostic assaying of iduronate-2-sulfatase (I2S), a lysosomal en...

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Detalles Bibliográficos
Autores principales: Schwarz, Markus, Skrinjar, Philipp, Fink, Michael J., Kronister, Stefan, Mechtler, Thomas, Koukos, Panagiotis I., Bonvin, Alexandre M. J. J., Kasper, David C., Mikula, Hannes
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2020
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8163285/
https://www.ncbi.nlm.nih.gov/pubmed/34094461
http://dx.doi.org/10.1039/d0sc04696e

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8163285/
https://www.ncbi.nlm.nih.gov/pubmed/34094461
http://dx.doi.org/10.1039/d0sc04696e

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