Mechanism and origins of selectivity in the enantioselective oxa-Pictet–Spengler reaction: a cooperative catalytic complex from a hydrogen bond donor and chiral phosphoric acid

Enantioselective additions to oxocarbenium ions are high-value synthetic transformations but have proven challenging to achieve. In particular, the oxa-Pictet–Spengler reaction has only recently been rendered enantioselective. We report experimental and computational studies on the mechanism of this...

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Detalles Bibliográficos
Autores principales: Maskeri, Mark A., Brueckner, Alexander C., Feoktistova, Taisiia, O'Connor, Matthew J., Walden, Daniel M., Cheong, Paul Ha-Yeon, Scheidt, Karl A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2020
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8163393/
https://www.ncbi.nlm.nih.gov/pubmed/34123127
http://dx.doi.org/10.1039/d0sc03250f

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8163393/
https://www.ncbi.nlm.nih.gov/pubmed/34123127
http://dx.doi.org/10.1039/d0sc03250f

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