TMTHSI, a superior 7-membered ring alkyne containing reagent for strain-promoted azide–alkyne cycloaddition reactions

We describe the development of TMTH-SulfoxImine (TMTHSI) as a superior click reagent. This reagent combines a great reactivity, with small size and low hydrophobicity and compares outstandingly with existing click reagents. TMTHSI can be conveniently functionalized with a variety of linkers allowing...

Descripción completa

Detalles Bibliográficos
Autores principales: Weterings, Jimmy, Rijcken, Cristianne J. F., Veldhuis, Harald, Meulemans, Tommi, Hadavi, Darya, Timmers, Matt, Honing, Maarten, Ippel, Hans, Liskamp, Rob M. J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2020
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8163418/
https://www.ncbi.nlm.nih.gov/pubmed/34123155
http://dx.doi.org/10.1039/d0sc03477k
_version_ 1783700910393786368
author Weterings, Jimmy
Rijcken, Cristianne J. F.
Veldhuis, Harald
Meulemans, Tommi
Hadavi, Darya
Timmers, Matt
Honing, Maarten
Ippel, Hans
Liskamp, Rob M. J.
author_facet Weterings, Jimmy
Rijcken, Cristianne J. F.
Veldhuis, Harald
Meulemans, Tommi
Hadavi, Darya
Timmers, Matt
Honing, Maarten
Ippel, Hans
Liskamp, Rob M. J.
author_sort Weterings, Jimmy
collection PubMed
description We describe the development of TMTH-SulfoxImine (TMTHSI) as a superior click reagent. This reagent combines a great reactivity, with small size and low hydrophobicity and compares outstandingly with existing click reagents. TMTHSI can be conveniently functionalized with a variety of linkers allowing attachment of a diversity of small molecules and (peptide, nucleic acid) biologics.
format Online
Article
Text
id pubmed-8163418
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher The Royal Society of Chemistry
record_format MEDLINE/PubMed
spelling pubmed-81634182021-06-11 TMTHSI, a superior 7-membered ring alkyne containing reagent for strain-promoted azide–alkyne cycloaddition reactions Weterings, Jimmy Rijcken, Cristianne J. F. Veldhuis, Harald Meulemans, Tommi Hadavi, Darya Timmers, Matt Honing, Maarten Ippel, Hans Liskamp, Rob M. J. Chem Sci Chemistry We describe the development of TMTH-SulfoxImine (TMTHSI) as a superior click reagent. This reagent combines a great reactivity, with small size and low hydrophobicity and compares outstandingly with existing click reagents. TMTHSI can be conveniently functionalized with a variety of linkers allowing attachment of a diversity of small molecules and (peptide, nucleic acid) biologics. The Royal Society of Chemistry 2020-08-10 /pmc/articles/PMC8163418/ /pubmed/34123155 http://dx.doi.org/10.1039/d0sc03477k Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by-nc/3.0/
spellingShingle Chemistry
Weterings, Jimmy
Rijcken, Cristianne J. F.
Veldhuis, Harald
Meulemans, Tommi
Hadavi, Darya
Timmers, Matt
Honing, Maarten
Ippel, Hans
Liskamp, Rob M. J.
TMTHSI, a superior 7-membered ring alkyne containing reagent for strain-promoted azide–alkyne cycloaddition reactions
title TMTHSI, a superior 7-membered ring alkyne containing reagent for strain-promoted azide–alkyne cycloaddition reactions
title_full TMTHSI, a superior 7-membered ring alkyne containing reagent for strain-promoted azide–alkyne cycloaddition reactions
title_fullStr TMTHSI, a superior 7-membered ring alkyne containing reagent for strain-promoted azide–alkyne cycloaddition reactions
title_full_unstemmed TMTHSI, a superior 7-membered ring alkyne containing reagent for strain-promoted azide–alkyne cycloaddition reactions
title_short TMTHSI, a superior 7-membered ring alkyne containing reagent for strain-promoted azide–alkyne cycloaddition reactions
title_sort tmthsi, a superior 7-membered ring alkyne containing reagent for strain-promoted azide–alkyne cycloaddition reactions
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8163418/
https://www.ncbi.nlm.nih.gov/pubmed/34123155
http://dx.doi.org/10.1039/d0sc03477k
work_keys_str_mv AT weteringsjimmy tmthsiasuperior7memberedringalkynecontainingreagentforstrainpromotedazidealkynecycloadditionreactions
AT rijckencristiannejf tmthsiasuperior7memberedringalkynecontainingreagentforstrainpromotedazidealkynecycloadditionreactions
AT veldhuisharald tmthsiasuperior7memberedringalkynecontainingreagentforstrainpromotedazidealkynecycloadditionreactions
AT meulemanstommi tmthsiasuperior7memberedringalkynecontainingreagentforstrainpromotedazidealkynecycloadditionreactions
AT hadavidarya tmthsiasuperior7memberedringalkynecontainingreagentforstrainpromotedazidealkynecycloadditionreactions
AT timmersmatt tmthsiasuperior7memberedringalkynecontainingreagentforstrainpromotedazidealkynecycloadditionreactions
AT honingmaarten tmthsiasuperior7memberedringalkynecontainingreagentforstrainpromotedazidealkynecycloadditionreactions
AT ippelhans tmthsiasuperior7memberedringalkynecontainingreagentforstrainpromotedazidealkynecycloadditionreactions
AT liskamprobmj tmthsiasuperior7memberedringalkynecontainingreagentforstrainpromotedazidealkynecycloadditionreactions

Ejemplares similares