USP8 is a Novel Therapeutic Target in Melanoma Through Regulating Receptor Tyrosine Kinase Levels

INTRODUCTION: The hyperactivation of receptor tyrosine kinase (RTK)-mediated pathways plays an important role in melanoma progression and resistance to therapy. The ubiquitin-specific protease 8 (USP8) is a deubiquitinating enzyme and its inhibition induces degradation of RTKs. This work explored th...

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Detalles Bibliográficos
Autores principales: Duan, Baoxue, Wang, Changying, Liu, Zeng, Yang, Xiaoyu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2021
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8163583/
https://www.ncbi.nlm.nih.gov/pubmed/34079371
http://dx.doi.org/10.2147/CMAR.S300195

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8163583/
https://www.ncbi.nlm.nih.gov/pubmed/34079371
http://dx.doi.org/10.2147/CMAR.S300195

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