FAK inhibition alone or in combination with adjuvant therapies reduces cancer stem cell activity

Cancer stem-like cells (CSC) contribute to therapy resistance and recurrence. Focal adhesion kinase (FAK) has a role in CSC regulation. We determined the effect of FAK inhibition on breast CSC activity alone and in combination with adjuvant therapies. FAK inhibition reduced CSC activity and self-ren...

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Detalles Bibliográficos
Autores principales: Timbrell, Simon, Aglan, Hosam, Cramer, Angela, Foden, Phil, Weaver, David, Pachter, Jonathan, Kilgallon, Aoife, Clarke, Robert B., Farnie, Gillian, Bundred, Nigel J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8163772/
https://www.ncbi.nlm.nih.gov/pubmed/34050172
http://dx.doi.org/10.1038/s41523-021-00263-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8163772/
https://www.ncbi.nlm.nih.gov/pubmed/34050172
http://dx.doi.org/10.1038/s41523-021-00263-3

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