Selective targeting of non-centrosomal AURKA functions through use of a targeted protein degradation tool

Targeted protein degradation tools are becoming a new therapeutic modality, allowing small molecule ligands to be reformulated as heterobifunctional molecules (PROteolysis Targeting Chimeras, PROTACs) that recruit ubiquitin ligases to targets of interest, leading to ubiquitination and destruction of...

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Detalles Bibliográficos
Autores principales: Wang, Richard, Ascanelli, Camilla, Abdelbaki, Ahmed, Fung, Alex, Rasmusson, Tim, Michaelides, Iacovos, Roberts, Karen, Lindon, Catherine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8163823/
https://www.ncbi.nlm.nih.gov/pubmed/34050235
http://dx.doi.org/10.1038/s42003-021-02158-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8163823/
https://www.ncbi.nlm.nih.gov/pubmed/34050235
http://dx.doi.org/10.1038/s42003-021-02158-2

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