Structures of the human LONP1 protease reveal regulatory steps involved in protease activation

The human mitochondrial AAA+ protein LONP1 is a critical quality control protease involved in regulating diverse aspects of mitochondrial biology including proteostasis, electron transport chain activity, and mitochondrial transcription. As such, genetic or aging-associated imbalances in LONP1 activ...

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Detalles Bibliográficos
Autores principales: Shin, Mia, Watson, Edmond R., Song, Albert S., Mindrebo, Jeffrey T., Novick, Scott J., Griffin, Patrick R., Wiseman, R. Luke, Lander, Gabriel C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8163871/
https://www.ncbi.nlm.nih.gov/pubmed/34050165
http://dx.doi.org/10.1038/s41467-021-23495-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8163871/
https://www.ncbi.nlm.nih.gov/pubmed/34050165
http://dx.doi.org/10.1038/s41467-021-23495-0

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