Intratumoral SIRPα-deficient macrophages activate tumor antigen-specific cytotoxic T cells under radiotherapy

Radiotherapy (RT)-induced tumoricidal immunity is severely limited when tumors are well-established. Here, we report that depleting SIRPα on intratumoral macrophages augments efficacy of RT to eliminate otherwise large, treatment-resistant colorectal (MC38) and pancreatic (Pan02 and KPC) tumors, ind...

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Detalles Bibliográficos
Autores principales: Bian, Zhen, Shi, Lei, Kidder, Koby, Zen, Ke, Garnett-Benson, Charlie, Liu, Yuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8163884/
https://www.ncbi.nlm.nih.gov/pubmed/34050181
http://dx.doi.org/10.1038/s41467-021-23442-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8163884/
https://www.ncbi.nlm.nih.gov/pubmed/34050181
http://dx.doi.org/10.1038/s41467-021-23442-z

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