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Non-canonical NRF2 activation promotes a pro-diabetic shift in hepatic glucose metabolism
OBJECTIVE: NRF2, a transcription factor that regulates cellular redox and metabolic homeostasis, plays a dual role in human disease. While it is well known that canonical intermittent NRF2 activation protects against diabetes-induced tissue damage, little is known regarding the effects of prolonged...
Autores principales: | , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8164084/ https://www.ncbi.nlm.nih.gov/pubmed/33933676 http://dx.doi.org/10.1016/j.molmet.2021.101243 |