Autoinhibition of Cnn binding to γ-TuRCs prevents ectopic microtubule nucleation and cell division defects

γ-Tubulin ring complexes (γ-TuRCs) nucleate microtubules. They are recruited to centrosomes in dividing cells via binding to N-terminal CM1 domains within γ-TuRC–tethering proteins, including Drosophila Centrosomin (Cnn). Binding promotes microtubule nucleation and is restricted to centrosomes in di...

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Detalles Bibliográficos
Autores principales: Tovey, Corinne A., Tsuji, Chisato, Egerton, Alice, Bernard, Fred, Guichet, Antoine, de la Roche, Marc, Conduit, Paul T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8164090/
https://www.ncbi.nlm.nih.gov/pubmed/34042945
http://dx.doi.org/10.1083/jcb.202010020

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8164090/
https://www.ncbi.nlm.nih.gov/pubmed/34042945
http://dx.doi.org/10.1083/jcb.202010020

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