Effects of orlistat combined with enzalutamide and castration through inhibition of fatty acid synthase in a PC3 tumor-bearing mouse model

Androgen deprivation therapy (ADT) is one of the typical treatments used for patients with prostate cancer (PCa). ADT, however, may fail when PCa develops castration-resistance. Fatty acid synthase (FASN), a critical enzyme involved in fatty acid synthesis, is found to be up-regulated in PCa. Since...

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Detalles Bibliográficos
Autores principales: Tyan, Yeu-Sheng, Lee, Yen-Po, Chuang, Hui-Yen, Wang, Wei-Hsun, Hwang, Jeng-Jong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Portland Press Ltd. 2021
Materias:
Cancer
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8164108/
https://www.ncbi.nlm.nih.gov/pubmed/33974005
http://dx.doi.org/10.1042/BSR20204203

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8164108/
https://www.ncbi.nlm.nih.gov/pubmed/33974005
http://dx.doi.org/10.1042/BSR20204203

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