Selinexor decreases HIF-1α via inhibition of CRM1 in human osteosarcoma and hepatoma cells associated with an increased radiosensitivity

BACKGROUND: The nuclear pore complexes (NPCs) are built of about 30 different nucleoporins and act as key regulators of molecular traffic between the cytoplasm and the nucleus for sizeable proteins (> 40 kDa) which must enter the nucleus. Various nuclear transport receptors are involved in import...

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Detalles Bibliográficos
Autores principales: von Fallois, Moritz, Kosyna, Friederike Katharina, Mandl, Markus, Landesman, Yosef, Dunst, Jürgen, Depping, Reinhard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2021
Materias:
Original Article – Cancer Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8164574/
https://www.ncbi.nlm.nih.gov/pubmed/33856525
http://dx.doi.org/10.1007/s00432-021-03626-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8164574/
https://www.ncbi.nlm.nih.gov/pubmed/33856525
http://dx.doi.org/10.1007/s00432-021-03626-2

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