Simultaneously targeting SOAT1 and CPT1A ameliorates hepatocellular carcinoma by disrupting lipid homeostasis

Lipid homeostasis plays a fundamental role in the development of hepatocellular carcinoma (HCC). However, the mechanisms that regulate lipid homeostasis to avoid lipotoxicity in HCC remain elusive. Here, we found high-fat diet (HFD) improved the expression of sterol o-acyltransferase1 (SOAT1) and ca...

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Detalles Bibliográficos
Autores principales: Ren, Meiling, Xu, Huanji, Xia, Hongwei, Tang, Qiulin, Bi, Feng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8164629/
https://www.ncbi.nlm.nih.gov/pubmed/34052835
http://dx.doi.org/10.1038/s41420-021-00504-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8164629/
https://www.ncbi.nlm.nih.gov/pubmed/34052835
http://dx.doi.org/10.1038/s41420-021-00504-1

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