Improved SARS-CoV-2 M(pro) inhibitors based on feline antiviral drug GC376: Structural enhancements, increased solubility, and micellar studies

Replication of SARS-CoV-2, the coronavirus causing COVID-19, requires a main protease (M(pro)) to cleave viral proteins. Consequently, M(pro) is a target for antiviral agents. We and others previously demonstrated that GC376, a bisulfite prodrug with efficacy as an anti-coronaviral agent in animals,...

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Detalles Bibliográficos
Autores principales: Vuong, Wayne, Fischer, Conrad, Khan, Muhammad Bashir, van Belkum, Marco J., Lamer, Tess, Willoughby, Kurtis D., Lu, Jimmy, Arutyunova, Elena, Joyce, Michael A., Saffran, Holly A., Shields, Justin A., Young, Howard S., Nieman, James A., Tyrrell, D. Lorne, Lemieux, M. Joanne, Vederas, John C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Masson SAS. 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8164773/
https://www.ncbi.nlm.nih.gov/pubmed/34118724
http://dx.doi.org/10.1016/j.ejmech.2021.113584

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8164773/
https://www.ncbi.nlm.nih.gov/pubmed/34118724
http://dx.doi.org/10.1016/j.ejmech.2021.113584

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