Gene Regulatory Network Analysis and Engineering Directs Development and Vascularization of Multilineage Human Liver Organoids

Pluripotent stem cell (PSC)-derived organoids have emerged as novel multicellular models of human tissue development but display immature phenotypes, aberrant tissue fates, and a limited subset of cells. Here, we demonstrate that integrated analysis and engineering of gene regulatory networks (GRNs)...

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Detalles Bibliográficos
Autores principales: Velazquez, Jeremy J., LeGraw, Ryan, Moghadam, Farzaneh, Tan, Yuqi, Kilbourne, Jacquelyn, Maggiore, Joseph C., Hislop, Joshua, Liu, Silvia, Cats, Davy, de Sousa Lopes, Susana M. Chuva, Plaisier, Christopher, Cahan, Patrick, Kiani, Samira, Ebrahimkhani, Mo R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8164844/
https://www.ncbi.nlm.nih.gov/pubmed/33290741
http://dx.doi.org/10.1016/j.cels.2020.11.002

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8164844/
https://www.ncbi.nlm.nih.gov/pubmed/33290741
http://dx.doi.org/10.1016/j.cels.2020.11.002

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