Cargando…

The Heat Sensing Trpv1 Receptor Is Not a Viable Anticonvulsant Drug Target in the Scn1a (+/−) Mouse Model of Dravet Syndrome

Cannabidiol has been approved for the treatment of drug-resistant childhood epilepsies including Dravet syndrome (DS). Although the mechanism of anticonvulsant action of cannabidiol is unknown, emerging data suggests involvement of the transient receptor potential cation channel subfamily V member 1...

Descripción completa

Detalles Bibliográficos
Autores principales:	Satpute Janve, Vaishali, Anderson, Lyndsey L., Bahceci, Dilara, Hawkins, Nicole A., Kearney, Jennifer A., Arnold, Jonathon C.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2021
Materias:	Pharmacology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8165383/ https://www.ncbi.nlm.nih.gov/pubmed/34079465 http://dx.doi.org/10.3389/fphar.2021.675128

Ejemplares similares

Heterozygous deletion of Gpr55 does not affect a hyperthermia-induced seizure, spontaneous seizures or survival in the Scn1a(+/)(-) mouse model of Dravet syndrome
por: Anderson, Lyndsey L., et al.
Publicado: (2023)

Ictal vocalizations in the Scn1a (+/−) mouse model of Dravet syndrome
por: Anderson, Lyndsey L., et al.
Publicado: (2023)

The anticonvulsant phytocannabinoids CBGVA and CBDVA inhibit recombinant T-type channels
por: Udoh, Michael, et al.
Publicado: (2022)

Olivetolic acid, a cannabinoid precursor in Cannabis sativa, but not CBGA methyl ester exhibits a modest anticonvulsant effect in a mouse model of Dravet syndrome
por: Anderson, Lyndsey L., et al.
Publicado: (2022)

Delayed maturation of GABAergic signaling in the Scn1a and Scn1b mouse models of Dravet Syndrome
por: Yuan, Yukun, et al.
Publicado: (2019)

Efficacy of Stiripentol in Dravet Syndrome with or without SCN1A Mutations
por: Cho, Min Jung, et al.
Publicado: (2018)

Dravet syndrome: a new causative SCN1A mutation?
por: Poryo, Martin, et al.
Publicado: (2017)

Drug repurposing for Dravet syndrome in scn1Lab (−/−) mutant zebrafish
por: Sourbron, Jo, et al.
Publicado: (2019)

C57BL/6J and C57BL/6N substrains differentially influence phenotype severity in the Scn1a (+/−) mouse model of Dravet syndrome
por: Kang, Seok K., et al.
Publicado: (2018)

Dravet Syndrome in Lebanon: First Report on Cases with SCN1A Mutations
por: Alame, Saada, et al.
Publicado: (2019)

Augmented Reticular Thalamic Bursting and Seizures in Scn1a-Dravet Syndrome
por: Ritter-Makinson, Stefanie, et al.
Publicado: (2019)

Augmented Reticular Thalamic Bursting and Seizures in Scn1a-Dravet Syndrome
por: Ritter-Makinson, Stefanie, et al.
Publicado: (2019)

TANGO With SCN1A: Can This Molecular Dance Defeat Dravet Syndrome?
por: Wagnon, Jacy L.
Publicado: (2020)

Heat-induced seizures, premature mortality, and hyperactivity in a novel Scn1a nonsense model for Dravet syndrome
por: Mavashov, Anat, et al.
Publicado: (2023)

SCN1B and SCN2B gene variants analysis in dravet syndrome patients: Analysis of 22 cases
por: Gong, Jiao-E., et al.
Publicado: (2019)

Unexpected Efficacy of a Novel Sodium Channel Modulator in Dravet Syndrome
por: Anderson, Lyndsey L., et al.
Publicado: (2017)

Identification of SCN1A and PCDH19 Mutations in Chinese Children with Dravet Syndrome
por: Kwong, Anna Ka-Yee, et al.
Publicado: (2012)

Morphometry and network-based atrophy patterns in SCN1A-related Dravet syndrome
por: Lenge, Matteo, et al.
Publicado: (2023)

SCN1A Gene Mutation and Adaptive Functioning in 18 Vietnamese Children with Dravet Syndrome
por: Do, Thi Thu Hang, et al.
Publicado: (2017)

Behavioral Comorbidities and Drug Treatments in a Zebrafish scn1lab Model of Dravet Syndrome
por: Grone, Brian P., et al.
Publicado: (2017)

SCN1A Mutation—Beyond Dravet Syndrome: A Systematic Review and Narrative Synthesis
por: Ding, Jiangwei, et al.
Publicado: (2021)

Screening of conventional anticonvulsants in a genetic mouse model of epilepsy
por: Hawkins, Nicole A., et al.
Publicado: (2017)

Scn8a Antisense Oligonucleotide Is Protective in Mouse Models of SCN8A Encephalopathy and Dravet Syndrome
por: Lenk, Guy M., et al.
Publicado: (2020)

Cannabis constituents interact at the drug efflux pump BCRP to markedly increase plasma cannabidiolic acid concentrations
por: Anderson, Lyndsey L., et al.
Publicado: (2021)

SCN1A Genetic Test for Dravet Syndrome (Severe Myoclonic Epilepsy of Infancy and its Clinical Subtypes) for use in the Diagnosis, Prognosis, Treatment and Management of Dravet Syndrome
por: Stenhouse, Susan A.R., et al.
Publicado: (2013)

Fine Mapping of a Dravet Syndrome Modifier Locus on Mouse Chromosome 5 and Candidate Gene Analysis by RNA-Seq
por: Hawkins, Nicole A., et al.
Publicado: (2016)

Drug screening in Scn1a zebrafish mutant identifies clemizole as a potential Dravet Syndrome treatment
por: Baraban, Scott C., et al.
Publicado: (2013)

Not all SCN1A epileptic encephalopathies are Dravet syndrome: Early profound Thr226Met phenotype
por: Sadleir, Lynette G., et al.
Publicado: (2017)

Multimodal Analysis of SCN1A Missense Variants Improves Interpretation of Clinically Relevant Variants in Dravet Syndrome
por: Gonsales, Marina C., et al.
Publicado: (2019)

Beyond Dravet Syndrome: Characterization of a Novel, More Severe SCN1A-Linked Epileptic Encephalopathy
por: Beck, Veronica C., et al.
Publicado: (2019)

Epilepsy and neuropsychiatric comorbidities in mice carrying a recurrent Dravet syndrome SCN1A missense mutation
por: Ricobaraza, Ana, et al.
Publicado: (2019)

The dose makes the poison—Novel insights into Dravet syndrome and SCN1A regulation through nonproductive splicing
por: Helbig, Ingo, et al.
Publicado: (2021)

Transfer of SCN1A to the brain of adolescent mouse model of Dravet syndrome improves epileptic, motor, and behavioral manifestations
por: Mora-Jimenez, Lucia, et al.
Publicado: (2021)

Dravet Variant SCN1A(A1783V) Impairs Interneuron Firing Predominantly by Altered Channel Activation
por: Layer, Nikolas, et al.
Publicado: (2021)

The Role of Focal Epilepsy Features in Defining SCN1A Mutation-positive Dravet Syndrome as Generalized and Focal Epilepsy
por: Ko, Young Jun, et al.
Publicado: (2021)

Parental mosaicism in another case of Dravet syndrome caused by a novel SCN1A deletion: a case report
por: Sharkia, Rajech, et al.
Publicado: (2016)

Amplicon Resequencing Identified Parental Mosaicism for Approximately 10% of “de novo” SCN1A Mutations in Children with Dravet Syndrome
por: Xu, Xiaojing, et al.
Publicado: (2015)

Author Correction: Epilepsy and neuropsychiatric comorbidities in mice carrying a recurrent Dravet syndrome SCN1A missense mutation
por: Ricobaraza, Ana, et al.
Publicado: (2021)

Inhibitory synaptic transmission is impaired at higher extracellular Ca(2+) concentrations in Scn1a(+/−) mouse model of Dravet syndrome
por: Uchino, Kouya, et al.
Publicado: (2021)

Scn1a gene reactivation after symptom onset rescues pathological phenotypes in a mouse model of Dravet syndrome
por: Valassina, Nicholas, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_3o6vetvoqteuu1pf8h3ombdgjf