The use of minimal topological differences to inspire the design of novel tetrahydroisoquinoline analogues with antimalarial activity

A quantitative structure-activity relationship (QSAR) study was conducted using nineteen previously synthesized, and tested 1-aryl-6-hydroxy-1,2,3,4-tetrahydroisoquinolines with proven in vitro activities against Plasmodium falciparum. In order to computationally design and screen potent antimalaria...

Descripción completa

Detalles Bibliográficos
Autores principales: Ngo Hanna, Joelleinsert, Nziko, Vincent de Paul N., Ntie-Kang, Fidele, Mbah, James A., Toze, Flavien A.A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8165424/
https://www.ncbi.nlm.nih.gov/pubmed/34095565
http://dx.doi.org/10.1016/j.heliyon.2021.e07032

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8165424/
https://www.ncbi.nlm.nih.gov/pubmed/34095565
http://dx.doi.org/10.1016/j.heliyon.2021.e07032

Ejemplares similares