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The use of minimal topological differences to inspire the design of novel tetrahydroisoquinoline analogues with antimalarial activity
A quantitative structure-activity relationship (QSAR) study was conducted using nineteen previously synthesized, and tested 1-aryl-6-hydroxy-1,2,3,4-tetrahydroisoquinolines with proven in vitro activities against Plasmodium falciparum. In order to computationally design and screen potent antimalaria...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Elsevier
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8165424/ https://www.ncbi.nlm.nih.gov/pubmed/34095565 http://dx.doi.org/10.1016/j.heliyon.2021.e07032 |