Re-emerging Aspartic Protease Targets: Examining Cryptococcus neoformans Major Aspartyl Peptidase 1 as a Target for Antifungal Drug Discovery

[Image: see text] Cryptococcosis is an invasive infection that accounts for 15% of AIDS-related fatalities. Still, treating cryptococcosis remains a significant challenge due to the poor availability of effective antifungal therapies and emergence of drug resistance. Interestingly, protease inhibito...

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Detalles Bibliográficos
Autores principales: Kryštůfek, Robin, Šácha, Pavel, Starková, Jana, Brynda, Jiří, Hradilek, Martin, Tloušt’ová, Eva, Grzymska, Justyna, Rut, Wioletta, Boucher, Michael J., Drąg, Marcin, Majer, Pavel, Hájek, Miroslav, Řezáčová, Pavlína, Madhani, Hiten D., Craik, Charles S., Konvalinka, Jan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2021
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8165695/
https://www.ncbi.nlm.nih.gov/pubmed/34006103
http://dx.doi.org/10.1021/acs.jmedchem.0c02177

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8165695/
https://www.ncbi.nlm.nih.gov/pubmed/34006103
http://dx.doi.org/10.1021/acs.jmedchem.0c02177

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