Nanoparticle-enabled innate immune stimulation activates endogenous tumor-infiltrating T cells with broad antigen specificities

Tumors are often infiltrated by T lymphocytes recognizing either self- or mutated antigens but are generally inactive, although they often show signs of prior clonal expansion. Hypothesizing that this may be due to peripheral tolerance, we formulated nanoparticles containing innate immune stimulants...

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Detalles Bibliográficos
Autores principales: Yin, Qian, Yu, Wong, Grzeskowiak, Caitlin L., Li, Jing, Huang, Huang, Guo, Jing, Chen, Liang, Wang, Feng, Zhao, Fan, von Boehmer, Lotta, Metzner, Thomas J., Leppert, John T., Chien, Yueh-hsiu, Kuo, Calvin J., Davis, Mark M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2021
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8166076/
https://www.ncbi.nlm.nih.gov/pubmed/34021082
http://dx.doi.org/10.1073/pnas.2016168118

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8166076/
https://www.ncbi.nlm.nih.gov/pubmed/34021082
http://dx.doi.org/10.1073/pnas.2016168118

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