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Heparin-binding VEGFR1 variants as long-acting VEGF inhibitors for treatment of intraocular neovascular disorders

Neovascularization is a key feature of ischemic retinal diseases and the wet form of age-related macular degeneration (AMD), all leading causes of severe vision loss. Vascular endothelial growth factor (VEGF) inhibitors have transformed the treatment of these disorders. Millions of patients have bee...

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Detalles Bibliográficos
Autores principales: Xin, Hong, Biswas, Nilima, Li, Pin, Zhong, Cuiling, Chan, Tamara C., Nudleman, Eric, Ferrara, Napoleone
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8166142/
https://www.ncbi.nlm.nih.gov/pubmed/34006633
http://dx.doi.org/10.1073/pnas.1921252118