A synDNA vaccine delivering neoAg collections controls heterogenous, multifocal murine lung and ovarian tumors via robust T cell generation

Neoantigens are tumor-specific antigens that arise due to somatic mutations in the DNA of tumor cells. They represent ideal targets for cancer immunotherapy since there is minimal risk for on-target, off-tumor toxicities. Additionally, these are foreign antigens that should be immunogenic due to lac...

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Detalles Bibliográficos
Autores principales: Bhojnagarwala, Pratik S., Perales-Puchalt, Alfredo, Cooch, Neil, Sardesai, Niranjan Y., Weiner, David B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2021
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8166642/
https://www.ncbi.nlm.nih.gov/pubmed/34141866
http://dx.doi.org/10.1016/j.omto.2021.04.005

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8166642/
https://www.ncbi.nlm.nih.gov/pubmed/34141866
http://dx.doi.org/10.1016/j.omto.2021.04.005

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