Lectins engineered to favor a glycan-binding conformation have enhanced antiviral activity

Homologues of the Oscillatoria agardhii agglutinin (OAA) lectins contain a sequence repeat of ∼66 amino acids, with the number of tandem repeats varying across family members. OAA homologues bind high-mannose glycans on viral surface proteins, thereby interfering with viral entry into host cells. As...

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Detalles Bibliográficos
Autores principales: Matoba, Yasuyuki, Sato, Yuichiro, Oda, Kosuke, Hatori, Yuta, Morimoto, Kinjiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8166773/
https://www.ncbi.nlm.nih.gov/pubmed/33895142
http://dx.doi.org/10.1016/j.jbc.2021.100698

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8166773/
https://www.ncbi.nlm.nih.gov/pubmed/33895142
http://dx.doi.org/10.1016/j.jbc.2021.100698

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